Previous experience with phages (in particular phage display) and other large biomacromolecular complexes.Įxperience with the use of affinity molecules such as nanobodies, scFvs and antibodies and their cloning/engineering.įamiliarity with in silico cloning tools such as SnapGene would be an advantage.Įxperience with structural bioinformatics and protein modelling would be a plus (particularly experience with UCSF Chimera and Python).Ī solid understanding of cellular physiology and/or immunology would be advantageous.Ī deep understanding of ‘synthetic biology components’ such as improved promoters and vector backbones would be ideal. Prior experience of working in industry/a commercial setting will be a significant advantage for an application for any of our positions.Įxperience (or a willingness to learn) protein purification such as chromatography would be a strong preference.Įxperience with high-throughput cloning and liquid handling robots would be a bonus.Įxperience in strain background selection and engineering for optimisation of yield. Knowledgeable about the latest developments and techniques in the field. Experience dealing with large assemblies is strongly preferred.Įxperience with the modern molecular biology toolkit, including: Western blotting, PCR, electrophoresis, sequencing, cloning, etc. Skills, Experience & Background KnowledgeĮxtensive experience in cloning recombinant proteins in bacterial backgrounds, in particular. PhD or equivalent experience in a relevant discipline, such as molecular genetics, cell biology, immunology, molecular biology, biochemistry or similar related field. In this position flexibility will be hugely advantageous as you will likely be called on to help support other aspects of the team such as during the running of bioreactors and protein purification. You will have the opportunity to take the reins in designing strategies for platform development which are agile, scalable, and make use of some of the most cutting edge techniques and technologies in synthetic biology. Support other members of the team with molecular biology needs, such as supporting Cell Biology with cell line engineering, or Up-stream Processing with expression optimisation etc.Īs a Synthetic/Molecular Biology Scientist, you will be responsible for designing and creating novel implementations of our core platform, comprising novel targeting modalities and payloads, as well as supporting the cloning and molecular biology needs of the wider team. In this position you will be expected to:Įngage with the team and external partners to understand where optimisations and new functionality can be built into our platform, and take the lead on designing cloning strategies to accomplish this.ĭeliver molecular cloning of novel payloads and targeting moieties for testing using cutting-edge molecular cloning and synthetic biology techniques. As such, being able to rapidly and accurately design modifications to platform implementations, and to incorporate new functionality is a critical part of the success of the platform, and we are seeking talented synthetic and molecular biologists to make this a reality. NanoSyrinx’s platform is built around a genetically encoded delivery system. Developed and optimized + stable cell lines from vector design, gene delivery and silencing to clonal selection.As a Synthetic/Molecular Biology Scientist, you will be responsible for the development of our core technology.Led a project on epithelial morphogenesis using D organoid cultures of MDCK cysts, resulting in submitted manuscript collaborated with teammates on a project resulting in publication and $k grant funding. Organized and flexible, perform and oversee multiple individual tasks simultaneously, ensuring quality and efficiency while remaining within deadlinesįluorescence-activated cell sorting (FACS)īioluminescence resonance energy transfer (BRET)įast protein liquid chromatography (FPLC)Įpithelial morphogenesis - Pr.Completed projects through teamwork and collaborations, being regarded as a positive and cooperative spirit.Independent design, execution, analysis, and reporting of research results, resulting in $k funding, published reviews, award for best conference presentation.Technical skills and research experience applicable to target identification and mechanism-of-action/pathway analysis, compound screening, development of complex cellular models and cellular assays.Epithelial cell biology scientist with a knack for solving complex problems and a strong record of research accomplishments resulting in peer-reviewed publications.After logging in, come back to this page and refresh your browser. This button will open the login/register page in a new tab.
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